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ea0044p235 | Thyroid | SFEBES2016

Hypothyroidism induces hyperplasia of unilocular adipocytes in perirenal adipose tissue of the ovine fetus

Harris Shelley E , De Blasio Miles J , Wooding FB Peter , Blache Dominique , Meredith David , Fowden Abigail L , Forhead Alison J

Thyroid hormones are important regulators of fetal growth, although their mechanism of action remains unclear. In the sheep fetus, thyroid hormone deficiency increases plasma insulin and leptin concentrations. This study investigated the effects of hypothyroidism on perirenal adipose tissue (PAT) development and adipose insulin signalling pathways in fetal sheep.All procedures were performed under the UK Animals (Scientific Procedures) Act 1986. In 10 tw...

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ea0070aep1104 | Hot topics (including COVID-19) | ECE2020

Hypothyroidism in utero suppresses pituitary-adrenal function in the ovine fetus near term: Implications for fetal maturation and the timing of birth

Camm Emily , Inzani Isabella , De Blasio Miles , Davies Katie , Lloyd India , Peter Wooding F. B. , Fowden Abigail , Forhead Alison

Development of the fetal hypothalamic-pituitary-adrenal (HPA) axis is important for normal maturation of the fetus and the timing of parturition. In hypothyroid fetuses, gestational length may be prolonged and maturational processes delayed, although the role of the HPA axis is unknown. This study investigated the effects of hypothyroidism before birth on the structure and function of the anterior pituitary and adrenal glands in fetal sheep near term.All...

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Endocrine Abstracts

Hypothyroidism induces hyperplasia of unilocular adipocytes in perirenal adipose tissue of the ovine fetus

Hypothyroidism in utero suppresses pituitary-adrenal function in the ovine fetus near term: Implications for fetal maturation and the timing of birth

BiosciAbstracts